The presence of extracapsular extension (ECE) in lymph node-positive head and neck squamous cell carcinoma (HNSCC) leads to poor locoregional control (LRC), distant control (DC) and overall survival (OS) [1–8]. Due to its poor prognosis, histologically identified ECE is an indication for more aggressive adjuvant treatment, with both an increased dose of post-operative radiotherapy (RT) and concurrent chemotherapy [9]. Evidence supporting this approach largely stems from two contemporaneous, separately designed and run, phase III randomized trials, EORTC 22931 and RTOG 95–01, and the meta-analysis of their pooled data [10–12].
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Ιατρική Αλέξανδρος Γ. Σφακιανάκης,Αναπαύσεως 5 Άγιος Νικόλαος 72100 Κρήτη 00302841026182 Medical Articles by Alexandros G.Sfakianakis PhD,Anapafseos 5 Agios Nikolaos 72100 Crete Greece 00306932607174
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Πέμπτη 2 Νοεμβρίου 2017
Extracapsular extension is associated with worse distant control and progression-free survival in patients with lymph node-positive human papillomavirus-related oropharyngeal carcinoma
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