Current Recommended Vitamin D Prenatal Supplementation and Fetal Growth: Results from China-Anhui Birth Cohort Study.

Current Recommended Vitamin D Prenatal Supplementation and Fetal Growth: Results from China-Anhui Birth Cohort Study.

J Clin Endocrinol Metab. 2017 Oct 31;:

Authors: Tao RX, Meng DH, Li JJ, Tong SL, Hao JH, Huang K, Tao FB, Zhu P

Abstract
Context: Maternal vitamin D insufficiency have been associated with fetal growth restriction. However, the effect ofmaternal vitamin D supplementation on fetal growth has not been confirmed.
Objective: To assess the effect of maternal vitamin D supplementation recommended byIOMduring pregnancy on the neonatal vitamin D status and the risk of small for gestational age (SGA).
Design and Participants: As part of the China-Anhui Birth Cohort study, maternal sociodemographic characteristics, food intake, lifestyle, information of vitamin D supplementation and birth outcomes were prospectively collected. For participants, 600 IU/d of vitamin D3 was routinely advised to take duringpregnancy.Cord blood levels of 25-hydroxyvitamin D [25(OH)D], calcium and phosphorus were measured in 1 491 neonates who were divided into three groups base on the duration of maternal vitamin D supplementation during pregnancy.
Results: Mean cord blood concentration of 25(OH)D were 3.5nmol/L higher (95% CI 0.8, 6.2) in neonates(median: 37.9 nmol/L)whose mother taking vitamin D supplement more than two months during pregnancy compared to those(median:34.3 nmol/L)whose mother didn't takeany supplement. The significant difference across the seasons. The adjusted risk of SGA in pregnant women with vitamin D supplementation more than two months was significantly decreased than that in women without any vitamin D supplementation (11.8% vs 6.9%; adjusted OR=0.53, 95% CI 0.32, 0.87).
Conclusions: The findings from the developing country suggestthat maternal vitamin D supplementation recommended by IOM resulting in a slight but significant higher fetal levels of 25(OH)D improves fetal growth.

PMID: 29096022 [PubMed - as supplied by publisher]

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