Feasibility of deep brain stimulation for controlling the lower urinary tract functions: An animal study.

Feasibility of deep brain stimulation for controlling the lower urinary tract functions: An animal study.

Clin Neurophysiol. 2017 Sep 30;128(12):2438-2449

Authors: Chen SC, Chu PY, Hsieh TH, Li YT, Peng CW

Abstract
OBJECTIVE: To evaluate the feasibility of deep brain stimulation (DBS) and compare the potential of four DBS targets in rats for regulating bladder activity: the periaqueductal gray (PAG), locus coeruleus (LC), rostral pontine reticular nucleus (PnO), and pedunculopontine tegmental nucleus (PPTg).
METHODS: A bipolar stimulating electrode was implanted. The effects of DBS on the inhibition and activation of micturition reflexes were investigated by using isovolumetric intravesical pressure recordings.
RESULTS: PAG DBS at 2-2.5 V, PnO DBS at 2-2.5 V, and PPTg DBS at 1.75-2.5 V nearly completely inhibited reflexive isovolumetric bladder contractions. By contrast, LC DBS at 1.75 and 2 V slightly augmented reflexive isovolumetric bladder contractions in rats. DBSs on PnO and PPTg at higher intensities (2.5-5 V) demonstrated a higher success rate and larger contraction area evocation in activating bladder contractions in a partially filled bladder. DBS targeting the PPTg was most efficient in suppressing reflexive isovolumetric bladder contractions.
CONCLUSION: PPTg DBS demonstrated stable results and high potency for controlling bladder contractions. PPTg might be a promising DBS target for developing new neuromodulatory approaches for the treatment of bladder dysfunctions.
SIGNIFICANCE: DBS could be a potential approach to manage bladder function under various conditions.

PMID: 29096218 [PubMed - as supplied by publisher]

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