Evidence of genotoxicity and cytotoxicity of x-rays in the oral mucosa epithelium of adults subjected to cone-beam computed tomography.

Evidence of genotoxicity and cytotoxicity of x-rays in the oral mucosa epithelium of adults subjected to cone-beam computed tomography.

Dentomaxillofac Radiol. 2017 Nov 01;:20170160

Authors: da Fonte JB, de Andrade TM, Albuquerque-Júnior RL, B de Melo MF, Takeshita WM

Abstract
OBJECTIVES: To assess cytological evidence of genotoxicity and cytotoxicity of X-rays in oral exfoliated cells of adults subjected to partial and total CBCT (stitching module) by means of micronuclei frequency, associated with counting of degenerative nuclear alterations (pyknosis, karyolysis, karyorrhexis, buds and broken eggs), besides comparing the partial and total CBCT (stitching module) in search of possible differences in the nature and/or intensity of the effects.
METHODS: Twenty-nine adults who were referred to total or partial CBCT were selected. All CBCT were performed with a Carestream CS 9000 3D scanner (Carestream Health Inc Rochester, NY, United States). Material collection was done immediately before CBCT and 10 days later, by scraping the left and right cheek mucosa with a plastic spatula. Statistical analysis was performed using the Wilcoxon test (paired data), at a significance level of 5%.
RESULTS: The statistically significant difference was noted in the frequency of micronucleated cells for both partial and total acquisition (p=0.008 and p<0.001, respectively). Regarding to cytotoxicity, there was a statistically significant difference for both partial and total acquisition (p<0.001 and p<0.001, respectively).
CONCLUSIONS: The partial and total CBCT seems to offer risks of inducing genetic damage. In addition both forms of cone-beam CT acquisition have promoted the induction of cytotoxic nuclear alterations.

PMID: 29091472 [PubMed - as supplied by publisher]

from PubMed via o.lakala70 on Inoreader http://ift.tt/2gXjILT
via IFTTT