Detection of Urate Crystals in Kidney Tissue

Wijkström and colleagues1 performed a kidney biopsy study on 19 male sugarcane workers with suspected Mesoamerican nephropathy. They used De Galantha staining on paraffin-embedded tissue to detect urate crystals. No uric acid crystals were found. I have several concerns regarding the apparent absence of urate crystals in the kidney biopsy specimens because urate crystalluria is not uncommon in sugarcane workers.2

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