The Microbiome and Biomarkers for Necrotizing Enterocolitis: Are We Any Closer to Prediction?

The past decade has seen a substantial increase in interest for biomarkers across a spectrum of disease states, fueled by emerging "omics" technologies. Biomarkers hold the promise of early detection and diagnosis, prognostication of disease severity, and new insights into disease mechanisms. Necrotizing enterocolitis (NEC) has been a prime target, with its high mortality, burden of morbidity in infants born preterm, and unpredictable onset.1,2 This review focuses on recent advances in NEC biomarker research, including the use of gut microbiome patterns of infants born preterm, and the application of new proteomic and metabolomic technology.

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