Prognostic Significance of Extensive Necrosis in Renal Cell Carcinoma

Few studies using the current classification of renal cell carcinoma (RCC) have looked at a large number of cases with near total necrosis. We identified 21 cases of resections of RCC with >90% necrosis from the archives of Johns Hopkins Hospital between 2000–2015. Patients' mean age was 59yrs. (43–77) with 16 (76%) males. 12 (57%) cases were papillary RCC, 4 (19%) clear cell papillary RCC, 4 (19%) clear cell RCC, 1 (5%) unclassified with sarcomatoid differentiation. International Society of Urological Pathology (ISUP) nucleolar grade was grade 1 (9 cases) or grade 2 (9 cases).

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