Centenarians Suffer from Significantly Lower Rates of Chronic Age-Related Disease than Younger Cohorts

Aging is an accumulation of molecular damage and its consequences. The greater the level of damage, the greater the dysfunction in organs and the immune system, then the closer the individual comes to the arbitrary dividing line at which that dysfunction becomes a formal, named age-related disease. Further, the more damage, the higher the mortality rate. Given this view of aging, it should be no great surprise to find that the longest lived people have a history of comparatively little age-related disease: the only ways to become extremely old are to either (a) have accumulated damage at a slower rate that everyone else, most likely through lifestyle choices, or (b) bear genetic variants that increase resistance to some forms of damage and consequence. In either case, cell and tissue damag...

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